NIMH

2006: New NIH antiviral results published. See abstract and published paper below; Goodkin (2006).

RECENT SCIENTIFIC ARTICLES

• Goodkin, K.,et. al., 2006. Cerebrospinal and peripheral human immunodeficiency virus type 1 load in a multisite, randomized, double-blind, placebo-controlled trial of D-Ala1-peptide T-amide for HIV-1-associated cognitive-motor impairment. J Neurovirol. 12:178-189.
  
  
• Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA)
  Maria T. Polianova, Francis W. Ruscetti, Candace B. Pert, Michael R. Ruff
  
  
• Antiviral and Immunological Benefits in HIV Patients Receiving Intranasal Peptide T (DAPTA)
  by Maria T Polianova, Francis W. Ruscetti, Candace B. Pert, Rochelle E. Tractenberg, Gifford Leoung, Scott Strang, and Michael R. Ruff
  
  
• Update on D-Ala-Peptide T-Amide (DAPTA): A Viral Entry Inhibitor that Blocks CCR5 Chemokine Receptors by Michael R. Ruff,
  Maria Polianova, Quan-en Yang, Gifford S. Leoung, Francis W. Ruscetti and Candace B. Pert
  
  
• Peptide T Bolus Normalizes the Growth Hormone Secretion Pattern in Two Children with AIDS by Charlotte Barbey-Morel,
  Kevin McDonnell, Candace B. Pert, MerriBeth Adams, Dean Farrand, Michael R. Ruff, and Michael D. Lumpkin
  
  
• Peptide T Inhibits HIV-1 Infection Mediated by the Chemokine Receptor-5 (CCR5) by Michael R. Ruff, Loyda M. Melendez-Guerrero, Quan-en Yang, Wen-Zhe Ho, Judy Mikovits, Candace B. Pert, and Francis Ruscetti
  
  
• Peptide T Blocks GP120/CCR5 Chemokine Receptor-Mediated Chemotaxis by Laura S. Redwine, Candace B. Pert, Janice D. Rone, Robin Nixon, Matthew Vance, Bryan Sandler, Michael D. Lumpkin, Douglas J. Dieter, and Michael R. Ruff

RECENT ABSTRACTS

• A gp120 octapeptide hotspot (env binding sequence) elicits potent, efficacious rabbit antibodies which neutralize diverse HIV strains

• New NIMH Clinical Data Shows Antiviral Efficacy

• D-Ala1-Peptide T-Amide (DAPTA) strongly suppresses HIV-1 replication in human primary macrophages and prevents HIV-1-related neuronal apoptosis

• CTL and Cytokine Changes in HIV Patients Receiving Peptide T Suggest Restoration of Immune Function

• Chemokines and Neuroinflammatory Disease: New Directions by Candace B. Pert, Susan Wilt, Susanna Rossi, and Michael Ruff

• Peptide T (DAPTA) Delays Disease Onset in a Rat Retroviral Neuroinflammatory Disease with Activated Microglia by Candace Pert, Sandra Ruscetti, Yahir Santiago, Michael Ruff and Susan G. Wilt